Biovorin 50 mg Injection is a derivative of folic acid which is chemically reduced and one of the several active. It is also known as calcium folinate. It is used to prevent side effects caused by methotrexate. ( Methotrexate is used to treat certain types of cancer) It can either prevent or decrease the harmful effects of methotrexate and pyrimethamine. It is also known as Folinic acid. Biovorin 50 mg Injection is available in oral form and injectable for IM and IV administration. The chemical formula of this drug is C20H23N7O7.

• Biovorin 50 mg Injection is given with methotrexate to avoid the harmful effects of methotrexate.
• While the patient is on methotrexate in diseases like Rheumatoid Arthritis, Biovorin 50 mg Injection is given as an additional treatment to prevent or lessen the side effects of methotrexate.
• protects against Bone marrow suppression or GI mucosa inflammation.
• It is also used with other drugs as a combined therapy to treat colon cancer.
• Also used in the treatment of Toxoplasmosis retinitis.
• It can be also be used in the treatment of cerebral folate deficiency (CFD). CFD is a syndrome in which the normal CSF levels of 5
• MTHF are not normalized with folic acid.

Biovorin 50 mg Injection is used in the treatment of serious blood cell disorders like anemia, neutropenia and thrombocytopenia, which is occurred as a side effect of some drugs like methotrexate, pyrimethamine, trimethoprim.

• Drowsiness
• Respiratory distress

• Nausea
• Urticaria
• Sleeplessness
• Uneasiness
• Fever
• Redness
• Abdominal pain
• Diarrhoea
• Vomiting

• Breathing difficulty
• Dizziness
• Severe allergic reaction
• Swelling all over the body

Biovorin 50 mg Injection is available as an oral form and injectable form, which is given IM ( intramuscular) and IV (Intravenous) The route of drug administration and the frequency and dosage of the drug must be decided by your health care professional.

Biovorin 50 mg Injection is also used to increase levels of folic acid. It wil enhance the activity of fluorouracil by stabilizing the bond of the active metabolite to the enzyme thymidylate synthetase.